I recently completed Sean Carroll's most recent book, The Big Picture: On the Origin of Life, Meaning and the Universe Itself. It is, undeniably, one of the best books I've read in the past few years and one that I will start recommending to everyone forthwith.
It's a book written entirely about physics which somehow manages to be a book about religion in spirituality. The closest comparison I can think of is Richard Dawkins' The Blind Watchmaker. It demolished a large number of rather deeply held religious beliefs, not by attacking them, per say, but simply by explaining what we actually knew about science.
Carroll is a theoretical physicist and cosmologist that works at Caltech. (I found out in one of the interviews that the desk in his office used to belong to one of my other heroes, the late Richard Feynman.) What Watchmaker did for biology, this book does for physics and cosmology and it's been long overdue.
Most people who stop learning about science in high school simply don't know just how much we actually know about the universe. It's very easy to make the (fallacious) leap from "I don't know" to "nobody knows" without skipping a beat. But the information is out there, and has been for a very long time.
Spirituality and religion survives largely by leveraging the unknown. Narratives about how the universe began and what happens after we die survive because very few people are willing to put in the years it takes to learn the science to prove them wrong. And for the most part, science stays politely silent in what is usually called "tolerance". But — as is extremely well explained in the book — the science that definitely disproves notions like the existence of the soul, the afterlife, and an anthropomorphic deity that takes an interest in our lives is really well understood.
It's gotten slightly worse in recent years because of the magical-sounding properties of quantum mechanics. They're only magical when they're poorly understood, so it's nice to have someone who actually understands them and their predictions explain them.
But establishing what we know is only part of the book. In the latter sections, he outlines the consequences of these scientific facts for more philosophical matters like meaning, purpose, free will and morality. It's a wonderful resource to have all of this addressed in one place.
If you don't want to splurge for the whole book, the author gives a fantastic interview at Inquiring Minds that's worth checking out. The interviewer, Indre Viskontas, says that some of the later sections actually made her cry. I didn't go quite that far, even though I cry at mostly anything, but I still definitely recommend the book, more or less to everyone.